CHF 958.10

1-24 hours

Delivery is possible through one of our partner pharmacies after consultation.

Swissmedic Nr.: 57843001
Index: 08.06.00

Pharmacode: 3458314
GTIN/EAN: 7680578430015
Markteintritt: 02.03.2007

Kategorie: B Mehrmalige Abgabe auf eine ärztliche Verschreibung hin.


Noxafil® (40 mg/ml)

Posaconazol (J02AC04)

105 ml

(0/5 , 404)

Um Noxafil® (40 mg/ml) kaufen zu können, benötigen Sie zunächst ein Rezept. Bei Deindoktor.ch können Sie im Rahmen einer Online-Sprechstunde per Webcam, mit dem Artz Ihrer Wahl, ein elektronische Rezept erhalten.

Das mit DeinDoktor.ch erhaltene Rezept kann in einer der 1400 Schweizer Apotheken verwendet werden. Wir organisieren mit einer unserer Partner-Apotheken eine Sendung Ihres Noxafil® (40 mg/ml)'s gegen Unterschrift (24h) oder dem Medikamenten-Taxi nach einer Online Sprechstunde, falls gewünscht.


No doctor is now available for video consultation.
Your received prescription through DeinDoktor.ch is usable to get your medicaments in any of the 1400 Swiss pharmacies or in the Swiss online pharmacies. We can arrange with one of our pharmacy-partners a delivery against signature (24h) or medicament-taxi after an online-consultation.

Noxafil wird auf Verschreibung des Arztes oder der Ärztin eingesetzt. Noxafil gehört zur Gruppe der so genannten Triazol-Antimykotika. Diese Arzneimittel werden zur Behandlung einer Vielzahl von Pilzinfektionen verwendet. Die Wirkung von Noxafil besteht darin, dass es einige Pilzarten, die Infektionen beim Menschen verursachen können, abtötet oder deren Wachstum hemmt.

Noxafil kann zur Vorbeugung von Pilzinfektionen bei Patienten verwendet werden, deren Immunsystem durch andere Arzneimittel oder Erkrankungen geschwächt sein kann.

Noxafil kann zur Behandlung der folgenden Arten von Pilzinfektionen bei Erwachsenen angewendet werden:

  • Infektionen, verursacht durch Pilze der Fusarium Familie, die sich während einer Behandlung mit Amphotericin B nicht gebessert haben oder wenn Amphotericin B abgesetzt werden musste;
  • Durch Pilze verursachte Infektionen, die Zustände, bekannt unter dem Namen Chromoblastomykose und Myzetom, verursachen, die sich während einer Behandlung mit Itraconazol nicht gebessert haben oder wenn Itraconazol abgesetzt werden musste;
  • Infektionen aufgrund von Pilzen genannt Coccidioides, die sich während einer Behandlung mit einem oder mit mehreren der folgenden Arzneimittel (Amphotericin B, Itraconazol oder Fluconazol) nicht gebessert haben oder wenn diese Arzneimittel abgesetzt werden mussten.

Dieses Medikament wurde Ihnen vom Arzt bzw. von der Ärztin zur Behandlung der gegenwärtigen Erkrankung verschrieben.

Jede Dosis Noxafil sollte mit Nahrungsmitteln oder einem Nahrungsergänzungsmittel, wenn Sie keine Nahrung zu sich nehmen können, eingenommen werden, um die Aufnahme zu verbessern. Siehe «Wie verwenden Sie Noxafil?» dieser Patienteninformation für weitere Informationen zur Einnahme der Suspension.

Hinweis für Diabetiker:

Noxafil enthält 1,75 g Glukose pro 5ml Suspension.

Sofern Sie aus irgendeinem Grund Ihre Zuckeraufnahme genau überwachen müssen, sollten Sie diesen Glukoseanteil berücksichtigen.

Dieses Arzneimittel enthält Glukose. Patienten mit Glukose-Galaktose-Malabsorption sollten es nicht einnehmen.

Noxafil darf nicht angewendet werden,

  • wenn Sie überempfindlich (allergisch) gegen Posaconazol oder einen der sonstigen Bestandteile von Noxafil sind.
  • wenn Sie Arzneimittel anwenden, die Mutterkornalkaloide (zur Behandlung von Migräne) enthalten. Posaconazol kann die Blutspiegel dieser Arzneistoffe erhöhen, was zu schweren Durchblutungsstörungen in einigen Körperpartien und zu Gewebeschädigung führen kann.
  • wenn Sie eines der folgenden Arzneimittel anwenden. Posaconazol kann die Blutspiegel dieser Arzneimittel erhöhen, was zu schweren Herzrhythmusstörungen führen kann:
    • Terfenadin (zur Behandlung von allergischen Reaktionen)
    • Astemizol (zur Behandlung von allergischen Reaktionen)
    • Cisaprid (zur Behandlung von Magenbeschwerden)
    • Pimozid (zur Behandlung des Tourette-Syndroms)
    • Halofantrin (zur Behandlung von Malaria)
    • Chinidin (zur Behandlung von Herzrhythmusstörungen).
  • wenn Sie Simvastatin, Lovastatin, Atorvastatin und einige ähnliche Arzneimittel (HMG-CoA-Reduktase-Hemmer oder Statine genannt) einnehmen, die dazu dienen, hohe Cholesterinwerte im Blut zu behandeln.

Bitte lesen Sie den Abschnitt «Wann ist bei der Einnahme von Noxafil Vorsicht geboten?», in dem weitere Arzneimittel aufgeführt sind, die mit Noxafil in Wechselwirkung treten können.

Bitte beachten Sie, dass Noxafil nur für Erwachsene und Jugendliche (älter als 13 Jahre) vorgesehen ist.

In Ergänzung zu den oben genannten Arzneimitteln, die nicht mit Posaconazol aufgrund des Risikos von Herzrhythmusstörungen eingenommen werden dürfen, gibt es weitere Arzneimittel, die unter Umständen ein höheres Risiko für Herzrhythmusstörungen bergen, wenn sie zusammen mit Posaconazol eingenommen werden. Stellen Sie sicher, dass Sie Ihren Arzt/Ihre Ärztin über alle Arzneimittel informieren, die Sie anwenden (verschreibungspflichtige und nicht verschreibungspflichtige).

Weisen Sie Ihren Arzt oder Ihre Ärztin darauf hin,

  • wenn bei Ihnen jemals Überempfindlichkeitsreaktionen gegen andere Arzneimittel aus der Azol- oder Triazol-Familie aufgetreten sind. Diese umfassen Ketoconazol, Fluconazol, Itraconazol und Voriconazol.
  • wenn Sie Leberprobleme haben oder hatten. Unter Umständen benötigen Sie dann während der Behandlung mit Noxafil spezielle Blutuntersuchungen.
  • wenn Sie Nierenprobleme haben und/oder Arzneimittel einnehmen, die die Nieren beeinträchtigen.
  • wenn bei Ihnen schwere Durchfälle oder Erbrechen auftreten, da diese die Wirksamkeit von Noxafil herabsetzen können.
  • wenn Ihnen jemals mitgeteilt wurde, dass folgende Zustände bei Ihnen vorliegen:
    • eine abnormale Herzrhythmus-Kurve (EKG), die auf ein Problem hinweist, das «langes QTc-Intervall» genannt wird
    • Herzmuskelschwäche oder Herzversagen
    • sehr langsamer Herzschlag
    • jegliche Herzrhythmusstörung
    • jegliches Problem bezüglich des Gehalts an Kalium, Magnesium oder Calcium im Blut.

Es liegen keine Informationen über die Wirkung von Noxafil auf die Verkehrstüchtigkeit und auf die Fähigkeit, Maschinen zu bedienen, vor. Bitte informieren Sie Ihren Arzt oder Ihre Ärztin, wenn bei Ihnen Symptome wie z.B. Schläfrigkeit oder verschwommenes Sehen auftreten, die Ihre Verkehrstüchtigkeit oder Ihre Fähigkeit, Maschinen zu bedienen, beeinträchtigen könnten.

Dieses Arzneimittel enthält Glukose. Patienten mit Glukose-Galaktose-Malabsorption sollten es nicht einnehmen.

Bitte beachten Sie die oben stehende Liste der Arzneimittel, die Sie nicht zusammen mit Noxafil einnehmen dürfen (siehe «Wann darf Noxafil nicht angewendet werden?»).

Andere Arzneimittel, die manchmal verabreicht werden können, während Sie Noxafil einnehmen, bedürfen unter Umständen besonderer Beachtung. Klären Sie mit Ihrem Arzt/Ihrer Ärztin ab, ob Sie die folgenden Arzneimittel weiterhin einnehmen dürfen.

Bestimmte Arzneimittel können die Posaconazol-Blutspiegel erhöhen (mögliche Erhöhung des Nebenwirkungsrisikos) oder absenken (möglicherweise Wirksamkeitsverlust).

Zu den Arzneimitteln, die den Posaconazol-Blutspiegel absenken, gehören:

  • Rifabutin und Rifampicin (zur Behandlung von bestimmten Infektionen). Wenn Sie bereits mit Rifabutin behandelt werden, sind Ihre Blutwerte und einige mögliche Nebenwirkungen auf Rifabutin zu überwachen.
  • Efavirenz und Fosamprenavir, die zur Behandlung von HIV angewendet werden.
  • Einige Arzneimittel, die angewendet werden, um Anfallsleiden zu behandeln oder vorzubeugen, wie z.B. Phenytoin, Carbamazepin, Phenobarbital, Primidon.
  • ?Arzneimittel, die zur Absenkung der Magensäure angewendet werden wie Cimetidin und Ranitidin oder Omeprazol und ähnliche Arzneimittel, sogenannte H2-Rezeptorantagonisten und Protonen-Pumpen-Hemmer.

Noxafil kann die Blutspiegel einiger anderer Arzneimittel erhöhen (möglicherweise Erhöhung des Nebenwirkungsrisikos). Hierzu gehören:

  • Vincristin, Vinblastin und andere Vinca-Alkaloide (zur Behandlung von Krebs)
  • Ciclosporin (findet in der Transplantationschirurgie Anwendung)
  • Tacrolimus und Sirolimus (findet in der Transplantationschirurgie Anwendung)
  • Rifabutin (zur Behandlung von bestimmten Infektionen)
  • Arzneimittel zur Behandlung von HIV, sogenannte Proteaseinhibitoren (einschliesslich Lopinavir und Atazanavir, die mit Ritonavir angewendet werden), und nicht-nukleoside Reverse-Transkriptase-Hemmer (NNRTIs)
  • Midazolam, Triazolam, Alprazolam und andere ähnliche Arzneimittel, genannt Benzodiazepine (Beruhigungs- oder Muskelentspannungsmittel)
  • Diltiazem, Verapamil, Nifedipin, Nisoldipin und andere Arzneimittel aus der Gruppe der Calciumantagonisten (zur Behandlung von Bluthochdruck)
  • Digoxin (zur Behandlung von Herzinsuffizienz)
  • Sulfonylharnstoffe wie Glipizid (zur Behandlung von hohem Blutzucker).

Informieren Sie Ihren Arzt bzw. Ihre Ärztin, oder Ihren Apotheker bzw. Ihre Apothekerin, wenn Sie

  • an anderen Krankheiten leiden,
  • Allergien haben oder
  • andere Arzneimittel (auch selbstgekaufte!) einnehmen!

Informieren Sie Ihren Arzt oder Ihre Ärztin, wenn Sie glauben, schwanger zu sein, oder wenn Sie schwanger sind, bevor Sie mit der Einnahme von Noxafil beginnen. Noxafil darf während der Schwangerschaft nur nach Absprache mit Ihrem Arzt oder Ihrer Ärztin angewendet werden. Frauen im gebärfähigen Alter müssen eine wirksame Methode zur Empfängnisverhütung während der Einnahme von Noxafil anwenden. Wenn Sie unter der Behandlung mit Noxafil schwanger werden, setzen Sie sich umgehend mit Ihrem Arzt oder Ihrer Ärztin in Verbindung.

Noxafil darf während der Stillzeit nicht angewendet werden.

Wenden Sie Noxafil immer genau nach den Anweisungen Ihres Arztes oder Ihrer Ärztin an. Ihr Arzt oder Ihre Ärztin wird Ihr Ansprechen auf die Behandlung und Ihren Gesundheitszustand überwachen, um die Dauer der Einnahme von Noxafil zu bestimmen und um zu überwachen, ob eine Änderung Ihrer täglichen Dosis notwendig ist.

Anwendungsgebiet

Dosis

Vorbeugung schwerwiegender Pilzinfektionen

Nehmen Sie dreimal täglich 200 mg (ein Löffel zu 5ml) der Suspension zusammen mit Nahrungsmitteln oder einem Nahrungsergänzungsmittel, wenn Sie keine Nahrung vertragen, ein.

Behandlung resistenter Pilzinfektionen

Nehmen Sie zweimal täglich 400 mg (zwei Löffel zu 5ml) der Suspension zusammen mit Nahrungsmitteln oder mit einem Nahrungsergänzungsmittel, wenn Sie keine Nahrung vertragen, ein. Wenn Sie keine Nahrungsmittel und kein Nahrungsergänzungsmittel zu sich nehmen können, wird Ihr Arzt Sie anweisen, viermal täglich 200 mg (ein Löffel zu 5ml) einzunehmen.

Flasche vor jeder Anwendung gut schütteln.

Wenn Sie eine grössere Menge von Noxafil angewendet haben, als Sie sollten: Wenn Sie befürchten, eine zu hohe Dosis eingenommen zu haben, wenden Sie sich bitte unverzüglich an Ihren Arzt oder Ihre Ärztin oder an einen Angehörigen eines Gesundheitsberufs.

Wenn Sie die Anwendung von Noxafil vergessen haben: Wenn Sie die Einnahme einer Dosis vergessen haben, nehmen Sie sie ein, sobald Sie sich daran erinnern und folgen Sie dann dem gewohnten Rhythmus. Ist jedoch schon fast der Zeitpunkt für die nächste Dosis erreicht, so nehmen Sie diese zum vorgesehenen Zeitpunkt ein. Nehmen Sie nicht die doppelte Dosis ein, wenn Sie die vorherige Einnahme vergessen haben.

Ändern Sie nicht von sich aus die verschriebene Dosierung. Wenn Sie glauben, das Arzneimittel wirke zu schwach oder zu stark, so sprechen Sie mit Ihrem Arzt oder Apotheker bzw. mit Ihrer Ärztin oder Apothekerin.

Noxafil ist eine weisse Suspension mit Kirscharoma zum Einnehmen. Es ist in Braunglasflaschen zu 105 ml erhältlich. Jede Flasche wird zusammen mit einem Messlöffel geliefert, mit dem die Suspension zum Einnehmen in Dosen von 2,5 ml und 5 ml abgemessen werden kann.

Die Flasche von Noxafil ist mit einem kindersicheren Verschluss versehen und muss wie folgt geöffnet werden: Drücken Sie den Plastikschraubverschluss nach unten, während Sie ihn im Gegenuhrzeigersinn drehen.

Wie alle Arzneimittel kann Noxafil Nebenwirkungen haben, die aber nicht bei jedem auftreten müssen. Informieren Sie im Zweifelsfall Ihren Arzt oder Ihre Ärztin.

Folgende Nebenwirkungen können bei der Einnahme von Noxafil auftreten:

Häufige Nebenwirkungen (treten bei mindestens 1 von 100 Patienten und höchstens bei 1 von 10 Patienten auf) sind:

Kopfschmerzen, Schwindel, Taubheitsgefühl oder Kribbeln

Schläfrigkeit

Übelkeit oder Erbrechen, Appetitverlust, Magenschmerzen, Durchfall, Magenbeschwerden, Blähungen, Mundtrockenheit

Veränderte Leberwerte

Hautausschlag

Schwächegefühl, Müdigkeit

Abfall der weissen Blutkörperchen (wodurch das Infektionsrisiko steigen kann)

Fieber

Abnormale Werte von Salzen im Blut.

Gelegentliche Nebenwirkungen (treten bei mindestens 1 von 1000 Patienten und höchstens bei 1 von 100 Patienten auf) sind:

Anämie, verminderte Anzahl der sogenannten Blutplättchen, die zur Blutgerinnung dienen, verminderte Anzahl einiger Arten von weissen Blutzellen, Vergrösserung der Lymphknoten

Allergische Reaktion

Hohe Blutspiegel von Glukose (Blutzucker)

Gefühls- oder Bewegungsstörungen, (unwillkürliches) Zittern, Krampfanfälle

Herzrhythmusstörungen einschliesslich schneller Herzschlag (Palpitationen), anormale Werte bei Herzuntersuchungen (wie EKGs, die den Herzrhythmus aufzeichnen)

Hoher oder niedriger Blutdruck

Bauchspeicheldrüsenentzündung

Leberentzündung, Leberschaden, Gelbsucht (Gelbfärbung der Haut oder der Augen)

Nierenfunktionsstörungen, Nierenversagen

Menstruationsstörungen

Verschwommenes Sehen

Haarausfall, Juckreiz

Geschwüre im Mund

Frösteln, generelles Unwohlsein oder Schwächegefühl

Schmerzen am ganzen Körper, einschliesslich in Muskeln oder Gelenken, Rückenschmerzen

Flüssigkeitsretention, veränderte Arzneimittelspiegel.

Seltene Nebenwirkungen (treten mindestens bei 1 von 10?000 Patienten und höchstens bei 1 von 1000 Patienten auf) sind:

Lungenentzündung und andere Lungenschädigungen

Verminderte Anzahl aller Blutzellen, Blutgerinnungsstörungen, Blutung

Schwere allergische Reaktionen, einschliesslich ausgedehnter, blasiger Ausschlag und Hautschuppung

Reduzierte Nebennierenfunktion

Veränderte Hirnfunktion, Ohnmacht

Schmerzen, Schwäche, Taubheitsgefühl oder Kribbeln im Arm oder Bein

Depression

Doppeltsehen, blinder oder dunkler Fleck im Gesichtsfeld

Hörprobleme

Herzversagen oder Herzanfall, Herzrhythmusstörungen

Schlaganfall, Blutgerinnsel im Gehirn, den Extremitäten oder der Lunge

Darmblutungen

Leber- und Milzvergrösserung, Druckschmerzhaftigkeit der Leber

Leberentzündung oder Leberversagen, die in seltenen Fällen tödlich sein können

Blasiger Ausschlag, grosse, violette Hautverfärbungen durch Einblutungen unterhalb der Haut

Nierenentzündung

Brustschmerzen

Schwellung des Gesichts oder der Zunge.

Wenn Sie Nebenwirkungen bemerken, die hier nicht beschrieben sind, sollten Sie Ihren Arzt oder Apotheker bzw. Ihre Ärztin oder Apothekerin informieren.

Das Arzneimittel darf nur bis zu dem auf dem Behälter mit «EXP» bezeichneten Datum verwendet werden.

Nicht in Reichweite von Kindern aufbewahren.

Bei Raumtemperatur (15-25 °C) lagern. Nicht einfrieren.

Verbleibt Ihnen vier Wochen nach dem ersten Öffnen Suspension in der Flasche, so dürfen Sie diese nicht mehr einnehmen. Bringen Sie Flaschen mit nicht eingenommener Suspension zurück zu Ihrem Apotheker oder Ihrer Apothekerin.

Weitere Auskünfte erteilt Ihnen Ihr Arzt oder Apotheker bzw. Ihre Ärztin oder Apothekerin. Diese Personen verfügen über die ausführliche Fachinformation.

1 ml orale Suspension enthält: 40 mg Posaconazol

Hilfsstoffe: Polysorbat 80*, flüssige Glucose*, Konservierungsmittel: Natriumbenzoat (E211) und Benzylalkohol, Vanillin, Aromatica und weitere Hilfsstoffe.

* aus gentechnisch verändertem Mais hergestellt

Hinweis für Diabetiker:

Noxafil enthält 1,75g Glukose pro 5ml Suspension.

57843 (Swissmedic).

In Apotheken nur gegen ärztliche Verschreibung.

Flaschen à 105 ml.

MSD MERCK SHARP & DOHME AG, Luzern.

Diese Packungsbeilage wurde im Oktober 2011 letztmals durch die Arzneimittelbehörde (Swissmedic) geprüft.

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